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The brain is a prime example of a complex system, where the pertinent interactions happen at the multiple spatial and temporal scales. These multiscale interactions are closely intertwined to produce macroscopic outcomes, which usually are our everyday cognitive processes or in some case pathologies such as epilepsy, Alzheimer disease, or Multiple sclerosis. The goal of the studies at Michigan is to understand mechanisms underlying these cognitive and/or pathological phenomena. Researchers at Michigan use state of the art theoretical and experimental approaches (as those mentioned above) to understand biomolecular as well as network mechanisms underlying brain function and pathologies.