Assistant Professor of Biophysics
qiongy@umich.eduOffice Information:
3301 Chemistry
phone: 734-764-4669
Current Highlighted Work and Publications
A robust and tunable mitotic oscillator in artificial cells
Qiong Yang, Ye Guan, Zhengda Li, Shiyuan Wang, Patrick M Barnes, Xuwen Liu, Haotian Xu, Minjun Jin, Allen P Liu
Abstract
Single-cell analysis is pivotal to deciphering complex phenomena like heterogeneity, bistability, and asynchronous oscillations, where a population ensemble cannot represent individual behaviors. Bulk cell-free systems, despite having unique advantages of manipulation and characterization of biochemical networks, lack the essential single-cell information to understand a class of out-of-steady-state dynamics including cell cycles. Here, by encapsulating Xenopus egg extracts in water-in-oil microemulsions, we developed artificial cells that are adjustable in sizes...
See MoreIncoherent Inputs Enhance the Robustness of Biological Oscillators
Z. Li, Q. Yang
Cell Systems 5(1): 72-81 e4 (2017)
Robust biological oscillators retain the critical ability to function in the presence of environmental perturbations. Although central architectures that support robust oscillations have been extensively studied, networks containing the same core vary drastically in their potential to oscillate, and it remains elusive what peripheral modifications to the core contribute to this functional variation. Here, we have generated a complete atlas of two- and three-node oscillators computationally, then ...
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