Professor; Associate Chair for Graduate Studies
lasimm@umich.eduOffice Information:
5068 BSB
phone: 734-647-2016
Office of the Chair; Molecular, Cellular, and Developmental Biology
Recent Publications
Simmons Lab paper in PNAS
Lyle Simmons
MutS is responsible for initiating the correction of DNA replication errors. To understand how MutS searches for and identifies rare base-pair mismatches, we characterized the dynamic movement of MutS and the replisome in real time using superresolution microscopy and single-molecule tracking in living cells. We report that MutS dynamics are heterogeneous in cells, with one MutS population exploring the nucleoid rapidly, while another MutS population moves to and transiently dwells at the replisome region, even in the absence of appreciable mismatch formation. Analysis of MutS motion shows that...
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