Skip to Content

Search: {{$root.lsaSearchQuery.q}}, Page {{$}}

EEB Thursday Seminar: Evolution of the essential gap gene giant causes hybrid inviability in Drosophila

Daniel R. Matute, Assistant Professor, Dept of Biology, UNC Chapel Hill
Thursday, October 11, 2018
4:00-5:00 PM
1060 Biological Sciences Building Map
Hybrids have reduced fitness because of faulty interactions among genes that have diverged between the pure species. The most extreme hybrid defect is inviability. Hybrids therefore provide an easy to screen phenotype to identify what genes and molecular pathways have functionally diverged as genomes differentiate. Here I identify the Drosophila melanogaster allele of the highly conserved and essential gap gene giant (gt) as a key genetic determinant of hybrid inviability in crosses with D. santomea. The presence of this allele in D. melanogaster/D. santomea hybrids causes an abdominal ablation not seen in either pure species. giant is a key developmental regulator whose role in anterior-posterior specification of the dipteran embryo is conserved over 100 million years. The interaction of giant with a second allele, tailless,tll, is involved in the hybrid defects observed in these Drosophila hybrids. These results indicate that even genes with crucial developmental roles that are conserved over vast evolutionary time scales can experience functional evolution that leads to inviability of hybrids
Building: Biological Sciences Building
Event Type: Lecture / Discussion
Tags: Biology, Biosciences, Ecology, Environment, Lecture, Research, Science
Source: Happening @ Michigan from Ecology and Evolutionary Biology, Program in Biology, EEB Thursday Seminars, Museum of Zoology, Research Museums Center