Clinical Science Brown Bag: Event-related potentials during affective response inhibition in individuals with bipolar I disorder & schizophrenia

Abstract:
Individuals with bipolar I disorder and psychotic disorders experience difficulties with executive control, relative to healthy individuals without a psychiatric diagnosis. Prior research suggests that impairments in response inhibition, a subcomponent of executive control, contribute to clinical symptoms and adverse outcomes. Alterations in event-related potentials (ERPs) elicited during response inhibition tasks (e.g. go/no-go) hold promise for informing shared and disorder-specific neural and cognitive mechanisms of these disorders. The current study examines the N200 and P300 ERPs during an emotional face go/no-go task in healthy individuals and individuals diagnosed with bipolar I disorder, schizoaffective disorder, or schizophrenia. Findings can inform similarities and differences across these disorders as well as targeted intervention to improve inhibitory control. Background, methodology, preliminary results, next directions, and implications will be discussed.