Arthur F. Thurnau Professor
Deborah E. Goldberg Distinguished University Professor
she/her
Office Information:
4010 BSB
phone: 734.763.1548
Molecular, Cellular, and Developmental Biology
Education/Degree:
Ph.D., University of Wisconsin - Madison, 2002
Recent Publications
Selection on noise constrains variation in a eukaryotic promoter
Patricia Wittkopp
Genetic variation segregating within a species reflects the combined activities of mutation, selection, and genetic drift. In the absence of selection, polymorphisms are expected to be a random subset of new mutations; thus, comparing the effects of polymorphisms and new mutations provides a test for selection1, 2, 3, 4. When evidence of selection exists, such comparisons can identify properties of mutations that are most likely to persist in natural populations2. Here we investigate how mutation and selection have shaped variation in a cis-regulatory sequence controlling gene expression by ...
See More