Assistant Research Scientist
About
Life has an end, so does an individual cell. The end-point when the cell encounters death, we call it “cell death”, defined by the process that cell loses its original function, structural integrity, and eventually is removed from the whole organism. Cell death is a fundamental biological process and dysregulation of cell death pathways has been implicated in many human diseases, such as cancer, stroke or neurodegeneration. We have discovered a yet unrecognized cell death pathway, herein named as Lysozincrosis, which is a highly regulated form of lytic cell death that mediated by lysosomal TRP channel activation, lysosomal Zn2+ release and consequent mitochondria damage (Cell Reports, 2021). My current research interest is to identify the molecular mechanism underlying Lysozincrosis, and develop molecular mechanism-based therapies to treat brain diseases, such as brain tumors.
Fields of Study
- Cell death, Stroke, Brain Metastases
Areas of Focus
- Cell Biology, Lysosome, Mitochondrion, ion channel
