About
Current research in the Duan lab focuses on studying phenotypic plasticity. Using a zebrafish epithelial model, the Duanlab has discovered several mechanisms regulating developmental and cell plasticity. Many of them are converged onto the nutrient sensitive insulin/insulin-like growth factor (IIS)-PI3 kinase-Akt-Tor signaling pathway.
Dr. Duan received his doctoral degree from University of Tokyo and was a postdoctoral fellow at University of Washington and University of North Carolina at Chapel Hill.
Recent Publications:
Liu, C., Li, S., Noer, P.R., Kjaer-Sorensen, K., Juhl, A. K., Goldstein, A., Ke, C., Oxvig, C., and Duan, C. (2020) The metalloproteinase Papp-aa controls epithelial cell quiescence to proliferation transition. eLife 2020;9:e52322. DOI: 10.7554/eLife.52322
Xin, Y., Malick, A., Hu, M., Liu, C., Batah, H., Xu, H., and Duan, C. (2019) Cell-autonomous regulation of epithelial cell quiescence by calcium channel Trpv6. eLife 8:e48003 DOI: 10.7554/eLife.48003
Liu, C.*, Xin, Y.*, Bai, Y., Lewin, G., He, G., Mai, K., and Duan, C. (2018) Ca2+ concentration-dependent premature death of igfbp5a-/- fish reveals a critical role of IGF signaling in adaptive epithelial growth. Science Signaling, 11, eaat2231. https://www.science.org/doi/full/10.1126/scisignal.aat2231.* equal contribution.
Field(s) of Study
- Molecular and Developmental Endocrinology
Areas of Focus
- Cell Biology
- Development
- Neurobiology & Animal Physiology
