About
Research in the Duan lab is directed towards understanding how peptide growth factors act to control development and growth. Our current research focuses on the insulin-like growth factor/insulin (IIS) signaling system. The Duan lab uses zebrafish and human cell cultures as experimental models. A combination of molecular, cell biological, biochemical, genetic, and genomic approaches are used to address physiological and developmental questions. Specific areas of current research activity include: (1) roles of growth factors in regulating cell proliferation, differentiation, migration and apoptosis during early development; (2) signal transduction mechanisms of growth factor actions; (3) transcriptional and post-transcriptional regulation of gene expression; and (4) roles of growth factors and hormones in regulating development, growth, and aging in response to hypoxia and nutrient restriction.
Dr. Duan received his Ph.D. degree from the University of Tokyo in 1991. He was a postdoctoral fellow at University of Washington and University of North Carolina at Chapel Hill.
Recent Publications
Liu, C., Li, S., Noer, P.R., Kjaer-Sorensen, K., Juhl, A. K., Goldstein, A., Ke, C., Oxvig, C., and Duan, C. (2020) The metalloproteinase Papp-aa controls epithelial cell quiescence to proliferation transition. eLife 2020;9:e52322. DOI: 10.7554/eLife.52322
Xin, Y., Malick, A., Hu, M., Liu, C., Batah, H., Xu, H., and Duan, C. (2019) Cell-autonomous regulation of epithelial cell quiescence by calcium channel Trpv6. eLife 8:e48003 DOI: 10.7554/eLife.48003
Liu, C.*, Xin, Y.*, Bai, Y., Lewin, G., He, G., Mai, K., and Duan, C. (2018) Ca2+ concentration-dependent premature death of igfbp5a-/- fish reveals a critical role of IGF signaling in adaptive epithelial growth. Science Signaling, 11, eaat2231. DOI: 10.1126/scisignal.aat2231. * equal contribution.
Field(s) of Study
- Molecular and Developmental Endocrinology
Areas of Focus
- Cell Biology
- Development
- Neurobiology & Animal Physiology
