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Uncovering new functions of RNA modifications in mRNA processing

Nicole Martinez, Yale University
Friday, February 26, 2021
12:00-1:30 PM
Virtual
Abstract: Emerging evidence indicates that eukaryotic messenger RNAs are extensively decorated with modified nucleosides that have the potential to regulate eukaryotic gene expression through effects on mRNA metabolism. This talk will describe the discovery that the RNA modification pseudouridine is installed co-transcriptionally to pre-mRNA at thousands of positions by multiple pseudouridine synthases, revealing an endogenous function of pre-mRNA pseudouridylation in pre-mRNA processing. This function of pseudouridine synthases is important for our understanding of the many diseases associated with human pseudouridine synthase dysregulation.


Host: JK Nandakumar
Building: Off Campus Location
Location: Virtual
Event Link:
Event Type: Workshop / Seminar
Tags: Basic Science, Biology, Biosciences, Bsbsigns, Science, seminar
Source: Happening @ Michigan from Department of Molecular, Cellular, and Developmental Biology