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Mathematical Biology Seminar

Timeseries analysis of stochastic systems with hidden components
Monday, September 9, 2019
12:00-12:50 PM
335 West Hall Map
Despite dramatic advances in experimental techniques, many facets of intracellular dynamics remain hidden, or can be measured only indirectly. In this talk, I will describe two strategies to analyze stochastic timeseries data from biological systems with hidden parts: replacement of multi-step process with a time delay distribution or quasi-steady-state. Then, I will illustrate how these strategies are applied to understand the processes of protein synthesis, which involves multiple steps such as transcription, translation, folding and maturation, but typically whose intermediates proteins cannot be measured. Furthermore, drugs are also cleared out from our body in multiple steps of metabolism. To estimate the rate of drug clearance, which is a critical factor determining the dose level, a canonical approach has been used in more than 65,000 published papers for last 30 years. I will point out the critical limitation of the canonical approach and propose an alternative approach, which leads to accurate and precise estimation of drug clearance rate. Speaker(s): Jae Kyoung Kim (Dept of Mathematical Sciences, KAIST, Korea)
Building: West Hall
Event Type: Workshop / Seminar
Tags: Mathematics
Source: Happening @ Michigan from Department of Mathematics