Applied Interdisciplinary Mathematics (AIM) Seminar
Stochastic modeling of mutant clone propagation during carcinogenesis
Carcinogenesis, the transformation from healthy tissue to invasive cancer, is characterized by the progressive accumulation of mutations in a small group of founder cells. This talk focuses on the spread of premalignant cells during the process of carcinogenesis in epithelial tissue, utilizing a spatial stochastic model of mutation accumulation and clonal expansion. We use this model to develop a measure of the length-scale of genetic heterogeneity during carcinogenesis. In addition, we study the rate of expansion of a mutant clone, and discuss the clinical implications that arise from differences in the underlying structure of the tissue. Speaker(s): Katie Storey (University of Michigan)
Building: | East Hall |
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Event Type: | Workshop / Seminar |
Tags: | Mathematics |
Source: | Happening @ Michigan from Department of Mathematics, Applied Interdisciplinary Mathematics (AIM) Seminar - Department of Mathematics |