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Applied Interdisciplinary Mathematics (AIM) Seminar

Stochastic modeling of mutant clone propagation during carcinogenesis
Friday, November 16, 2018
3:00-4:00 PM
1084 East Hall Map
Carcinogenesis, the transformation from healthy tissue to invasive cancer, is characterized by the progressive accumulation of mutations in a small group of founder cells. This talk focuses on the spread of premalignant cells during the process of carcinogenesis in epithelial tissue, utilizing a spatial stochastic model of mutation accumulation and clonal expansion. We use this model to develop a measure of the length-scale of genetic heterogeneity during carcinogenesis. In addition, we study the rate of expansion of a mutant clone, and discuss the clinical implications that arise from differences in the underlying structure of the tissue. Speaker(s): Katie Storey (University of Michigan)
Building: East Hall
Event Type: Workshop / Seminar
Tags: Mathematics
Source: Happening @ Michigan from Department of Mathematics, Applied Interdisciplinary Mathematics (AIM) Seminar - Department of Mathematics