Skip to Content

Search: {{$root.lsaSearchQuery.q}}, Page {{$root.page}}

CSCS Seminar: New data, models, and methods to guide SARS-CoV-2 vaccine design and vaccination programs that counter escape mutations

James Koopman, Epidemiology, School of Public Health, University of Michigan; Carl Simon, Complex Systems, Math, Public Policy, University of Michigan
Tuesday, March 2, 2021
11:30 AM-1:00 PM
Virtual
Join Link: myumi.ch/v2ZYv

ABSTRACT:
Before the emergence of escape mutants that now threaten pandemic control, we constructed and analyzed the first model integrating immune waning and escape mutations. In the model, escape mutants were not problematic until a year into the pandemic. After they emerged, vaccination could worsen the pandemic. We examined four patterns by which existing escape mutants could stimulate further escape mutations. These provide insights in how to pursue epitope specific model analyses. The time is ripe for this advance. The pandemic has unveiled new high-throughput methods to characterize immunity at an epitope specific and B and T cell specific levels. We will present our model and discuss how it could integrate systems immunology and systems epidemiology.
Building: Off Campus Location
Location: Virtual
Event Link:
Event Type: Workshop / Seminar
Tags: Biology, Biosciences, Covid-19, Natural Sciences, Public Health, Research
Source: Happening @ Michigan from The Center for the Study of Complex Systems, The College of Literature, Science, and the Arts, Ecology and Evolutionary Biology, Epidemiology, Department of Physics, Department of Molecular, Cellular, and Developmental Biology, Microbiology & Immunology