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CSCS Seminar | Stochastic fluctuations in cells: a problem to overcome or an opportunity to exploit?

Andreas Hilfinger, University of Toronto - Mississauga, Department of Chemical & Physical Sciences
Tuesday, October 3, 2023
11:30 AM-1:00 PM
747 Weiser Hall Map
Biological processes are complex and involve many components whose interactions are stochastic and only partially characterized. Instead of ignoring or guessing unknown details our work focuses on analyzing classes of complex processes that share some features but are left to vary arbitrarily in all unknown features. This allows us to derive impossibility constraints that can guide the design of synthetic biology applications and help us understand the operating principles of cellular processes. Additionally, I will discuss how invariants for classes of incompletely specified systems can be exploited to infer rate functions and causal interactions in complex systems from observing stochastic fluctuations of a small subset of components. Such approaches have the potential to turn quantitatively intractable complex systems into a sequence of solvable inference problems.

This talk will be recorded for later viewing.
Building: Weiser Hall
Event Type: Workshop / Seminar
Tags: Biophysics, Biosciences, Natural Sciences, Research
Source: Happening @ Michigan from The Center for the Study of Complex Systems, The College of Literature, Science, and the Arts, Department of Physics, LSA Biophysics