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Controllability and Dynamics of the 3D Genome

Tuesday, April 8, 2014
12:00 AM
4448 East Hall

The controllability of a dynamical system refers to the
possibility of driving its state to a specific target state by means of a
control input. Controllability of the dynamic 3D human genome will be
discussed in the context of cellular reprogramming and for our work within
the DARPA Biochronicity initiative that explores the genetic basis of
biological time. I will more generally discuss the concept of "network
controllability" and the potential impact of this work in other disciplines.

Department of Computational Medicine and Bioinformatics
Department of Mathematics, University of Michigan
Biological Network Cluster

Indika Rajapakse, Assistant Professor, Dept. of Computational Medicine and Bioinformatics, U-M