Anna Mapp is the 2015 The Emil Thomas Kaiser Award recipient from the Protein Society. The Emil Thomas Kaiser Award recognizes a recent, highly significant contribution in applying chemistry to the study of proteins.
Mapp is the Edwin Vedejs Collegiate Professor of Chemistry, Professor of Chemistry, LSA and Director, Chemical Biology Program and Research Professor in the Life Sciences Institute.
Mapp uses innovative chemical biology in which insight into protein-protein interactions is used to inspire the design, synthesis, and screening of small molecules that can then be used to modulate those interactions to provide molecular-level insight into how genes are regulated at the transcriptional level. Her work has captured the molecular detail of transcriptional activators interacting with the transcriptional machinery in vivo, defining the resulting complexes kinetically and thermodynamically, work that is regarded as a landmark accomplishment. Small molecules developed in her pioneering work are deployed not only as mechanistic probes, but also as first-generation, transcription-targeted therapeutics. Her research provide a quintessential example of successful scientific reductionism—distilling a complex biological problem into the realm of chemistry.
The award will be presented at the Annual Symposium of the The Protein Society in Barcelona, Spain in July 2015.
In 1995, The Protein Society established The Emil Thomas Kaiser Award. Kaiser’s highly original research, including the profoundly significant discovery of the necessity amphiphilic helices to biological life, can be said to have introduced a new field of chemistry.
Previous Kaiser award winners from UM include Carol Fierke (2014) and Michael Marletta (2007).