Professor of Physics and Biophysics
About
Professor Ogilvie studies the dynamics of biological systems over a diverse range of time and length-scales using the combined tools of nonlinear spectroscopy and microscopy. At the nanometer scale, her group uses ultrafast nonlinear spectroscopy to explore the role of protein dynamics in evolution’s search for protein structures that meet the challenges of biological function. These methods complement existing X-ray and NMR techniques by accessing a new time window that encompasses the fastest processes in biology, such as energy transfer. Her group also employs single molecule spectroscopy to uncover dynamics hidden in ensemble measurements and to address the more complex domain of protein-protein interactions. On yet a larger length-scale, the group is developing novel microscopies that, without the need for artificial labels, exploit molecular contrast to elucidate the role of proteins in orchestrating cellular processes.
Selected Publications
A. Niedringhaus, V. Policht, P. D. Laible, D. F. Bocian, D. Holten, C. Kirmaier, J. P.Ogilvie, Energy Transfer and Charge Separation in the Bacterial Reaction CenterProbed by Two Dimensional Electronic Spectroscopy, Proceedings of the NationalAcademy of Sciences, www.pnas.org/cgi/doi/10.1073/pnas.1721927115
A. Loukianov, J. Pan, A. Niedringhaus, S. S. Senlik, B. Berg and J. P. Ogilvie, Two dimensional electronic Stark spectroscopy, Journal of Physical Chemistry Letters,(2017) 8, 679-683. Selected as a “Spotlight” article for this journal.
G. D. Scholes, G. R. Fleming, L. X. Chen, A. Aspuru-Guzik, A. Buchleitner, D. F. Coker,G. S. Engel, R. van Grondelle, A. Ishizaki, D. M. Jonas, J. S. Lundeen, J. K. McCusker,S. Mukamel, J. P. Ogilvie, A. Olaya-Castro, M. A. Ratner, F. C. Spano, K. B. Whaley, X.Zhu, Utilizing Coherence to Enhance Function in Chemical and Biophysical Systems Nature (2017) 543, 647-656.
S. Seckin Senlik, Veronica R. Policht, and Jennifer P. Ogilvie, Two-Color Nonlinear Spectroscopy for the Rapid Acquisition of Coherent Dynamics, Journal of PhysicalChemistry Letters (2015) 6, 2413-2420.
D. C. Flynn, A. R. Bhagwat, M. H. Brenner, M. F. Nunez, B. E. Mork, D. Cai, J. A.Swanson and J. P. Ogilvie Pulse-shaping based two-photon FRET stoichiometry, OpticsExpress (2015) 23, 3353-3372.
F. D. Fuller, and J. P. Ogilvie, Experimental Implementations of Two-Dimensional Fourier Transform Electronic Spectroscopy, Annual Reviews of Physical Chemistry(2015) 66, 667-690.
F. D. Fuller, J. Pan, A. Gelzinis, V. Butkus, S. S. Senlik, D. E. Wilcox, C. F. Yocum, L.Valkunas, D. Abramavicius, Jennifer P. Ogilvie, Vibronic Coherence in the Photosystem II Reaction Center, Nature Chemistry (2014) 6, 706–711.
M. H. Brenner, D. W. Cai, J. A. Swanson, J. P. Ogilvie, Two-photon imaging of multiple fluorescent proteins by phase-shaping and linear unmixing with a single broadband laser, Optics Express (2013) 21, 17256-17264.
A. Gelzinis, F. D. Fuller, L. Valkunas, J. P. Ogilvie, S. Mukamel, D. Abramavicius, Tight-binding model of the photosystem II reaction center: application to two-dimensional spectroscopy. New Journal of Physics (2013) 15, 075013.
K. L. M. Lewis, J. P. Ogilvie, Probing photosynthetic energy and charge transfer with two-dimensional electronic spectroscopy. Journal of Physical Chemistry Letters (2012) 3, 503-510 (cover article).
J. A. Myers, K. L. M. Lewis, F. D. Fuller, P. F. Tekavec, C. F. Yocum and J. P. Ogilvie, Two-dimensional electronic spectroscopy of the D1-D2- cyt 559 photosystem II reaction center Journal of Physical Chemistry Letters, (2010) 1, 19 2774-2780.
Field(s) of Study
