Congratulations to Abby Bigham who appears as second author on a research article in the most recent issue of Science! The article is entitled, "Evolution of Functional Impact of Rare coding Variation from Deep Sequencing of Human Exomes."
Michigan Anthropology biological anthropology colleague Milford Wolpoff says, "Some of her best work has been on the parallel high altitude adaptations in the Andes and in Tibet. One reason they are parallel is that the dramatically expanding human population of the Late Pleistocene and Holocene makes it really difficult for an adaptation that evolved in region to spread to another (geneticists call these selective sweeps). In this paper she is part of a group that looks at a quite different result of the population expansion, the accumulation of rare, individually different genes in people that do not disappear in spite of the fact that many of the rare variants contribute to disease susceptibility. Selection cannot work effectively in expanding populations to "weed these out", despite their consequences. It's a brilliant and important piece of work."
For those in the know, Science is the top-flight venue for scientific work. An appearance there puts you in the top ranks. See the link here for more: