Kopelman Lab: Nanoparticles + photoacoustic imaging-- a route to better cancer treatment decisions?
- News
-
- Search News
-
- Dreyfus-Teacher Scholar Award for Szymczak
- Sanford Named to AAAS
- Biemann Medal for Hakansson
- Sanford Honored with Election to National Academy of Sciences
- McNeil Lab: A more accurate sensor for lead paint
- Schindler Named 2016 Packard Fellow
- Sloan Fellowships for Pratt and Schindler
- Walter Lab: Resolving Subcellular miRNA Trafficking and Turnover at Single-Molecule Resolution
- Maldonado Lab: Cheaper, greener way to grow cystalline seminconductor films
- New polymer allows researchers to study how proteins fold, function
- Researchers focus on cell membranes to develop Alzheimer's treatments
- Video: Research on Lipid Bilayer and Relation to Amyloid-β
- Biteen Lab: Accounting for the "scooching effect"
- Pratt Lab: Molecular Iodine Found in Arctic Atmosphere
- Marsh & McNeil Named AAAS Fellows
- Ramamoorthy Lab: Nanodiscs catch mis-folding amyloid proteins
- Ault Named 2018 Sloan Fellow
- Biteen Lab: Starch Utilization System Assembles around Stationary Starch-Binding Proteins
- Biteen Lab: Starch Utilization System Assembles around Stationary Starch-Binding Proteins
- Pratt & Ault Labs: Harmful algal blooms can become airborne
- Meet Professor Bunsen Burns
- Shedding New Light on Photosynthetic Pigments
- Ruotolo Lab: New Method to ID Proteins
- Energy Research And Education Fuel McCrory CAREER Award
- Building Motors to Drive Nanorobots
- Fast, sensitive mass spectrometer will help UM chemists profile proteins and metabolites
- Award Season for Michigan Chemistry
- Chem Alum Receives Honorary Degree, Gives Rackham Commencement Address
- Alum Named Science Teacher of the Year
- MichiganChem boosts facility for atomic resolution
- DOE Early Career Award for Kerri Pratt
- ACS Honors Alum Weihong Tan
- Michigan Adds Chemistry Education Faculty Position
- Mapp Lab: New research clarifies how ‘fuzzy’ proteins can be used to develop novel drugs
- Karle Symposium Showcases Our Innovative Research
- UM scientists improve synthesis of PET imaging molecules
- MichiganChem Goes to the North Pole
- Diversity Service Award for Nicolai Lehnert
- Two elected Fellows of Royal Society of Chemistry
- Graduate Student Coordinator Honored
- 2018 Mentoring Award Recognizes Unique Programs
- Chen Named AAAS Fellow
- Chem 211 makes organic chem lab real for intro students
- Stephenson Lab: Designing a safer drug building block through photocatalysis
- "Compute-To-Learn" Bridges Classroom to Real-World Experiences
- Meet Roy Wentz: Chemistry's Custom Glassblower
- Michigan Students to Organize American Chemical Society Grad Symposium
- Anna Mapp honored for exceptional efforts to recruit and mentor students from non-traditional backgrounds
- Chemistry Alums Boyd and Pérez-Temprano Named to Talented 12
- Sharing Chemistry with the Community
- Awards Luncheon Offers Recognition for Outstanding Students
- Chemistry Faculty and Staff Collect Honors for Their Work
- Chemistry Writing: More Than Just Lab Reports
- Featured on the UM Gateway: Chemistry D-RISE Alum
- Hot climate, cool science :: Novel instrumentation applied to Arctic atmosphere earns Pratt "40 under 40" honors
- Kennedy Awarded Martin Medal for Achievements in Separation Science
- UM Chemists finding new opportunities in quantum science
- Alumna Sumita Mitra Inducted into National Inventors Hall of Fame
- Walter lab: RNA molecule senses a small metal ion to ramp up bacterium’s detox machine
- Create for Chemistry art contest
- Matzger Lab: A fix for insoluble drugs
- Dope Labs podcast explores the science behind pop culture phenomena
- Travel begets new data and new insights for Michigan Chem grad students
- Kopelman Lab: Nanoparticles + photoacoustic imaging-- a route to better cancer treatment decisions?
- Wang Lab: A productive first year
- National ACS Awards for Four Michigan Faculty
- Montgomery Named Thurnau Professor
- Mental Health, Well-Being and Research
- U-M to 3M: Transitioning to Industry after your PhD
- Chemistry Coping with COVID-19
- Chem Alums Create Crowdfunding Platform
- NSF Graduate Research Fellowships Announced
- Chem Master's Application Re-opened
- Chemistry Awards Announced
- New podcast: "My Fave Queer Chemist”
- Meet Josh Buss
- M|CORE: Preview program lowers barriers to graduate school
- Soellner Joins Michigan Chemistry
- Meet Chem Lecturer Nicole Tuttle
- Archived News
- UM Chemistry Featured Elsewhere
- Events
Photoacoustic imaging using nanoparticles to both image tumors and reveal information about their chemical environment is the subject of a perspective by Professor Raoul Kopelman in ACS Analytical Chemistry. A specific illustration of this technique for measuring oxygen levels in tumors that was recently published in ACS Nano.
When used with photoacoustic imaging, nanoparticles provide way to investigate tumors in living organisms in real time, even if the tumor is deep within an organism, Kopelman explains.
Photoacoustic imaging uses light and ultrasound to elicit a response from a signal molecule and to translate this response into precise information about a tumor and its chemical environment.
The nanoparticles’ key role is to protect the signal molecule until it is transported to the tumor. Without the nanoparticles, the signal molecule could react with other molecules in the blood before it even reaches a tumor, preventing its ability to give accurate information about the tumor.
Improving on exisiting diagnostic techniques
The combination of nanoparticles and photoacoustic imaging could give clinicians better information than that available with established techniques. For example, Kopelman explains, “CT and MRI have been around for a while. Each has had very important impacts on medicine, but they only provide structural imaging.”
Some techniques, like locally inserted electrodes, can provide chemical information but the electrodes can only be placed in some locations. “The patient’s chemical information provided to doctors has been lacking any details regarding its body location, distribution and time behavior," Kopelman points out. "Mostly, just blood and urine chemical tests have been available, and this hasn’t changed in a long time.”
In contrast, nanoparticles have the potential to find their way to all pertinent locations in the body and to provide real-time chemical information when used with photoacoustic imaging. For example, these nanoparticles have been used to more-effectively detect different chemicals in the environment around a tumor like oxygen (O2), acidity (low pH), and potassium ions (K+). Early detection could lead to more informed treatment decisions, specifically regarding choices of chemotherapy, radiation therapy, or immunotherapy. Kopelman puts it simply, “Different tumors need different methods of targeting.”
In the end, this combination of nanoparticles and photoacoustic imaging could change the way that cancer is diagnosed and treated. “The importance of this research is to provide critical chemical information about the tumor microenvironment to optimize doctors' decision-making on their choice of therapies for cancer patients,” Kopelman explains. "Rather than a 'one fits all' treatment protocol for cancer patients, this approach would allow for personalized medicine, a treatment that is tailor-made for the tumor of the patient, thus minimizing adverse side effects while maximizing the effectiveness of the therapy.”
More
ACS Analytical Chemistry Chemical Imaging in Vivo: Photoacoustic-Based 4-Dimensional Chemical Analysis
Chang H. Lee, Jeff Folz, Joel W. Y. Tan, Janggun Jo, Xueding Wang, and Raoul Kopelman Anal. Chem. 2019, 91, 2561−2569
ACS Nano "In Vivo Photoacoustic Lifetime Based Oxygen Imaging with Tumor Targeted G2 Polyacrylamide Nanosonophores"
Authors: Janggun Jo, Chang Heon Lee, Jeff Folz, Joel W. Y. Tan, Xueding Wang, Raoul Kopelman
UM Biomedical Engineering article on this technique "Reading cancer’s chemical clues"