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Dark Matter of the Human Genome

Sarah Slavoff (Yale University)
Thursday, November 4, 2021
4:00-5:30 PM
Off Campus Location
Advanced methods in next-generation sequencing and proteogenomics have revealed thousands of previously invisible human genes, increasing the known size of the human genome by at least 10%. This previously unannotated “dark matter” of the human genome includes small open reading frames (smORFs) encoding polypeptides of fewer than 100 amino acids, and alternative open reading frames (alt-ORFs) encoding proteins 100 amino acids or larger. Recent studies have shown that hundreds of smORFs are required for cell growth and survival, and some smORF-encoded polypeptides or “microproteins” bind to and regulate the activity of macromolecular complexes involved in critical cellular processes and disease. However, the vast majority of microproteins remain completely uncharacterized, and identifying their biological roles is now of paramount importance. I describe quantitative and (chemo)proteomic approaches to rapidly define the modifications, interactions, subcellular localizations, regulation and cellular and molecular phenotypes associated with newly discovered human microproteins, including key examples that regulate cell growth, ribosome biogenesis and/or mRNA decay.
Sarah Slavoff (Yale University)
Building: Off Campus Location
Location: Virtual
Event Type: Other
Tags: Biosciences, Chemistry, Science
Source: Happening @ Michigan from Department of Chemistry, Analytical Chemistry