Nitrogen Binding and Fixation using Iron Complexes

Nitrogen reduction (or "fixation") has been a longstanding target of study in chemistry because of the compelling goal of utilizing abundant, cheap atmospheric nitrogen for chemical synthesis. Current methods reduce nitrogen to ammonia at high temperatures and pressures. This seminar will discuss our research into low-temperature nitrogen fixation, as well as new mechanisms that lead to organic products from nitrogen. One of our strategies borrows from the natural enzyme, nitrogenase, which uses an unusual iron-sulfur cluster whose atomic-level mechanism is mysterious. This motivates the development of iron-sulfur complexes with unusual shapes, and study of their interactions with nitrogen and other nitrogenase substrates. Another strategy involves low-coordinate iron coordination compounds, which display new mechanisms for breaking the N-N bond of nitrogen. Studies on low-valent iron compounds have led to the first example of converting nitrogen and arenes directly into aniline products.




Pat Holland (Yale University)