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Recent Advances in Fluorine (Radio) chemistry

Veronique Gouverneur (University of Oxford)
Friday, February 16, 2018
2:00-3:30 PM
1640 Chem Chemistry Dow Lab Map
The success of Positron Emission Tomography (PET) and renewed interest in [18F]radiochemistry led to creative methods to incorporate 18F into molecules of increasing complexity. Despite these advances, clinically useful radiotracers lie within a narrow accessible space with [18F]fluoroalkanes and [18F]fluoroarenes at the forefront. Many potentially high value PET 18F-labeled tracers and drugs lie outside this radiochemical space, and the ability to test tracers not amenable to traditional or newly developed 18F-labeling intervention would be a major boost for PET imaging. A more diverse range of 18F-tags could immediately serve medicinal chemists by informing the selection of lead compounds much earlier in the drug discovery pipeline. This lecture will present our general approach to late stage 18F-fluorination and the recent contribution we have made to this field of research with the labeling of a range of 18F-tags for PET.



















Veronique Gouverneur (University of Oxford)
Building: Chemistry Dow Lab
Event Type: Other
Tags: Chemistry, Science
Source: Happening @ Michigan from Department of Chemistry