Elucidation of catalytic strategies of small nucleolytic ribozymes from combined experimental and theoretical approaches

The catalytic strategies that RNA uses to catalyze reactions have been examined for 40 years. I will present our labs latest efforts to elucidate how small nucleoyotic ribozymes catalyze chemical reactions. I will describe both experimental and theoretical approaches that we have taken on, with an emphasis of the last few years.

















Phil Bevilacqua (Penn State University)