MCDB 417 - Chromosome Structure and Function
Section: 001
Term: WN 2019
Subject: Molecular, Cellular, and Developmental Biology (MCDB)
Department: LSA Molecular, Cellular, and Developmental Biology
Requirements & Distribution:
With permission of instructor.
Enforced Prerequisites:
This course counts toward the 60 credits of math/science required for a Bachelor of Science degree.
May not be repeated for credit.
Rackham Information:
Rackham credit requires additional work.
Primary Instructor:

This course focuses on our current understanding of how chromosome structure affects its functions, both in interphase (gene regulation) and mitosis (chromosome segregation). Topics will include the step-wise assembly of interphase chromatin and mitotic chromosomes, and the properties of active euchromatin and inactive heterochromatin. We will also explore how chromatin structure changes as cells differentiate during development and as cells are reprogrammed to pluripotency in the germline or in vitro. Finally, we will examine how chromatin marks can be inherited during mitotic divisions or transgenerationally. Each topic will be introduced by a lecture that also incorporates in-class group activities designed to assimilate the knowledge students gained while completing reading assignments at home. This lecture and activity will be followed by in-class discussion of primary scientific literature to investigate the genetic, genomic, biochemical, and cytological methods for defining our current knowledge about chromosomes.

Course Requirements:

Students will be evaluated based on group presentations and in class quizzes on assigned papers, and a final written research proposal.

Intended Audience:

Primarily upper-level undergraduates concentrating in CMB or another biology-related program. It will also be of interest to graduate students in their first year of study.

Class Format:

Combination of lecture, in class discussion, and group work.

MCDB 417 - Chromosome Structure and Function
Schedule Listing
001 (LEC)
TuTh 8:30AM - 10:00AM
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