Noncoding RNA structure and recognition in stress response and immunity

The goal of our research is to gain a detailed structural and mechanistic understanding of cellular and viral noncoding RNAs (ncRNAs). Our recent work has focused on investigating how two archetypes of ncRNAs — the tRNA and the double-stranded RNA (dsRNA), as well as RNAs that mimic them, mediate cellular responses to stress, regulate HIV-1 replication, and modulate host innate immunity.