George Granger Brown Professor of Chemical Engineering, A.H. White Distinguished University Professor of Mechanical Engineering, Professor of Macromolecular Science and Engineering, Professor of Biomedical Engineering
rlarson@umich.eduOffice Information:
NCRC B-10
A150
2800 Plymouth Road
and
3062 H.H. Dow Building
2300 Hayward Street
Ann Arbor, MI 48109-2136
phone: 734.936.0772
Education/Degree:
Ph.D. University of Minnesota, Chemical Engineering, 1980M.S. University of Minnesota, Chemical Engineering, 1977
B.S. University of Minnesota, Chemical Engineering, 1975
About
Research Interests:
Rheology and Flow of Complex Fluids. Many everyday substances are not readily classified as solids or liquids, but have flow properties (i.e., rheology) somewhere in between. Such fluids typically have a polymeric or colloidal microstructure much larger than the atomic which dominates the rheological (i.e., flow) properties. Through rheological experiments, theory, and computer simulations, the Larson group is working out the relationship between the structure of these complex fluids and their rheology. Such knowledge is valuable in the optimal design of such fluids for applications in the polymer, pharmaceutical, and consumer products industries. Of particular interest at present are branched polymer melts, surfactant solutions, coating fluids, colloids and biopolymers. The group has current projects on the rheology of surfactant solutions, including those used in shampoos and body washes, and on the interfacial action of dispersants used in oil-spill clean up. We also have a project to determine how best to control the rheology of latex coatings. We are developing advanced theories for the rheological properties of entangled polymers with long-chain branching. We also helping design novel methods of high-speed manufacture of nanofibers, using rotary jet spinning. The work includes experimental, theoretical and computational components.
Molecular Simulations of Complex Fluids and Materials. Our group has multiple projects involving molecular simulations of polymers, surfactants, and colloids. These include molecular dynamics simulations at the atomistic level, starting from interactions between atoms derived in part from ab initio (quantum mechanical) calculations, coarse-grained molecular dynamics simulations, Brownian dynamics simulations, Stochastic Rotation Dynamics and Stokesian dynamics simulations. We are specifically looking at polymers in strong flows, at levels of resolution ranging from atomistic simulations of short chains to Brownian dynamics simulations of very long chains. This includes simple flows as well as flows of polymers through complex geometries, such as channels with contractions. We are also simulating self-assembling colloids, where anisotropic interactions between particles allow unique structures to self assemble and re-configure. We are carrying out atomistic and coarse-grained simulations of latex particle dispersions to better control their flow properties. We are simulating the interactions between drugs and cellulosic polymers used to optimize their release in the body.
Polyelectrolyte Interactions. We are studying the complexes formed by polymers of opposite charge, which are used to make layer-by-layer assemblies used for drug delivery or structured materials. A special case is that of negatively charged DNA interacting with either positively charged proteins or positively charged nanoparticles. In particular, we are examining the process by which such proteins find their target sites along double-stranded DNA molecules, using both single-molecule imaging methods and theory.
Professional Experience:
Bell Laboratories
Member of Technical Staff, 1980-1996
Professional Service
AIChE Professional Progress Award Committee, 1999-2000
American Institute of Chemical Engineering
Ford Prize Committee, 1997-1998
American Physical Society
Fluid Mechanics Steering Committee, 1990-1995, 2001-present
American Institute of Chemical Engineering
Editorial Board – Rheol. Acta, 1994–present
Executive Committee, 1991-2001
Society of Rheology
President, Society of Rheology, 1997-1999
Society of Rheology
Awards:
Department of Chemical Engineering Outstanding Faculty Achievement Award, 2017
Department of Chemical Engineering, University of Michigan
Distinguished University Professorship, 2013
University of Michigan
Stephen S. Attwood Award, College of Engineering, 2013
University of Michigan
Member, 2003
National Academy of Engineering
Bingham Medal, 2002
Society of Rheology
Alpha Chi Sigma Award, 2000
American Institute of Chemical Engineers
Publication Award, Journal of Rheology, 1999
Excellence Award, 1998
Department of Chemical Engineering, University of Michigan
Prudential Distinguished Visiting Fellow, 1996
Cambridge University, England
Fellow, 1994
American Physical Society
Distinguished Member of Technical Staff, 1988
Bell Labs
Publications:
Books
Structure and Rheology of Molten Polymers: From Structure to Flow Behavior and Back Again, Hanser Gardner (2006)
Constitutive Equations for Polymer Melts and Solutions , Out of Print, photocopied versions can be ordered by email for a $20 fee for photocopy expenses from Ron Larson at rlarson@engin.umich.edu
The Structure and Rheology of Complex Fluids , Oxford University Press (1999)
Recent Journal Publications
W.J. Huang, Mandal, T., and R.G. Larson, Molecular Pharmaceutics 14:733-745 2017 “Computational Modeling of Hydroxypropyl-Methylcellulose Acetate Succinate (HPMCAS) and Phenytoin Interactions: A Systematic Coarse-Graining Approach.”
Y. Wei, M.J. Solomon, and R.G. Larson, J. Rheol. 60:1301-1315, 2016 “Quantitative Nonlinear Thixotropic Model with Stretched Exponential Response in Transient Shear Flows.”
H. Rezvantalab, D.J. Beltran-Villegas, and R.G. Larson, Phys. Rev. Lett., 117:128001 2016 “Rotator-to-Lamellar Phase Transition in Janus Colloids Driven by Pressure Anisotropy.”
A. Salehi, P. and R.G. Larson, Macromolecules 49:9706-9719 2016 “A Molecular Thermodynamic Model of Complexation in Mixtures of Oppositely Charged Polyelectrolytes with Explicit Account of Charge Association/Dissociation.”
F. Yuan and R.G. Larson J. Phys. Chem. B. 119:12540-12551 2015 “Multiscale Molecular Dynamics Simulations of Model Hydrophobically Modified Ethylene Oxide Urethane Micelles.”
P.S. Desai, B.-G. Kang, M. Katzarova, R. Hall, Q.F. Huang, S. Lee, M. Shivokhin, T. Chang, D.C. Venerus, J. Mays, J.D. Schieber, and R.G. Larson, Macromolecules 49:4964-4977 2016 “Challenging Tube and Slip-Link Models: Predicting the Linear Rheology of Well-Characterized Star and Linear 1,4-Polybutadienes.”
C.A.S. Batista, R.G. Larson, and N.A. Kotov, Science 350:6257 2015 “Nonadditivity of Nanoparticle Interactions.”
T. Mandal, R. Marson, and R.G. Larson, Soft Matter, 12: 8246-8255 2016 “Coarse-grained Modeling of Crystal Growth and Polymorphism of a Model Pharmaceutical Molecule.”
S. Wang, and R.G. Larson, Langmuir, 31:1262-1271, 2015 “Coarse-Grained Molecular Dynamics Simulation of Self-Assembly and Surface Adsorption of Surfactants Using an Implicit Water Model.”
F. Yuan, S. Wang, and R.G. Larson Langmuir, 31:1336-1343, 2015 “Potentials of Mean Force and Escape Times of Surfactants from Micelles and Hydrophobic Surfaces Using Molecular Dynamics Simulations.”
D.J. Beltran-Villegas, D.J. Schultz, B.A. Nguyen, H.P. Nguyen, S.C. Glotzer, and R.G. Larson, Soft Matter 10:4593-4602 2014 “Phase Behavior of Janus Colloids Determined by Sedimentation Equilibrium.” (cover article)
J. Liu and R.G. Larson, J. Chem. Phys. 138:174904 2013 “Brownian Dynamics Method for Simulation of Binding Kinetics of Patterned Colloidal Spheres with Hydrodynamic Interactions."
About
Research Interests:
Rheology and Flow of Complex Fluids. Many everyday substances are not readily classified as solids or liquids, but have flow properties (i.e., rheology) somewhere in between. Such fluids typically have a polymeric or colloidal microstructure much larger than the atomic which dominates the rheological (i.e., flow) properties. Through rheological experiments, theory, and computer simulations, the Larson group is working out the relationship between the structure of these complex fluids and their rheology. Such knowledge is valuable in the optimal design of such fluids for applications in the polymer, pharmaceutical, and consumer products industries. Of particular interest at present are branched polymer melts, surfactant solutions, coating fluids, colloids and biopolymers. The group has current projects on the rheology of surfactant solutions, including those used in shampoos and body washes, and on the interfacial action of dispersants used in oil-spill clean up. We also have a project to determine how best to control the rheology of latex coatings. We are developing advanced theories for the rheological properties of entangled polymers with long-chain branching. We also helping design novel methods of high-speed manufacture of nanofibers, using rotary jet spinning. The work includes experimental, theoretical and computational components.
Molecular Simulations of Complex Fluids and Materials. Our group has multiple projects involving molecular simulations of polymers, surfactants, and colloids. These include molecular dynamics simulations at the atomistic level, starting from interactions between atoms derived in part from ab initio (quantum mechanical) calculations, coarse-grained molecular dynamics simulations, Brownian dynamics simulations, Stochastic Rotation Dynamics and Stokesian dynamics simulations. We are specifically looking at polymers in strong flows, at levels of resolution ranging from atomistic simulations of short chains to Brownian dynamics simulations of very long chains. This includes simple flows as well as flows of polymers through complex geometries, such as channels with contractions. We are also simulating self-assembling colloids, where anisotropic interactions between particles allow unique structures to self assemble and re-configure. We are carrying out atomistic and coarse-grained simulations of latex particle dispersions to better control their flow properties. We are simulating the interactions between drugs and cellulosic polymers used to optimize their release in the body.
Polyelectrolyte Interactions. We are studying the complexes formed by polymers of opposite charge, which are used to make layer-by-layer assemblies used for drug delivery or structured materials. A special case is that of negatively charged DNA interacting with either positively charged proteins or positively charged nanoparticles. In particular, we are examining the process by which such proteins find their target sites along double-stranded DNA molecules, using both single-molecule imaging methods and theory.
Professional Experience:
Bell Laboratories
Member of Technical Staff, 1980-1996
Professional Service
AIChE Professional Progress Award Committee, 1999-2000
American Institute of Chemical Engineering
Ford Prize Committee, 1997-1998
American Physical Society
Fluid Mechanics Steering Committee, 1990-1995, 2001-present
American Institute of Chemical Engineering
Editorial Board – Rheol. Acta, 1994–present
Executive Committee, 1991-2001
Society of Rheology
President, Society of Rheology, 1997-1999
Society of Rheology
Awards:
Department of Chemical Engineering Outstanding Faculty Achievement Award, 2017
Department of Chemical Engineering, University of Michigan
Distinguished University Professorship, 2013
University of Michigan
Stephen S. Attwood Award, College of Engineering, 2013
University of Michigan
Member, 2003
National Academy of Engineering
Bingham Medal, 2002
Society of Rheology
Alpha Chi Sigma Award, 2000
American Institute of Chemical Engineers
Publication Award, Journal of Rheology, 1999
Excellence Award, 1998
Department of Chemical Engineering, University of Michigan
Prudential Distinguished Visiting Fellow, 1996
Cambridge University, England
Fellow, 1994
American Physical Society
Distinguished Member of Technical Staff, 1988
Bell Labs
Publications:
Books
Structure and Rheology of Molten Polymers: From Structure to Flow Behavior and Back Again, Hanser Gardner (2006)
Constitutive Equations for Polymer Melts and Solutions , Out of Print, photocopied versions can be ordered by email for a $20 fee for photocopy expenses from Ron Larson at rlarson@engin.umich.edu
The Structure and Rheology of Complex Fluids , Oxford University Press (1999)
Recent Journal Publications
W.J. Huang, Mandal, T., and R.G. Larson, Molecular Pharmaceutics 14:733-745 2017 “Computational Modeling of Hydroxypropyl-Methylcellulose Acetate Succinate (HPMCAS) and Phenytoin Interactions: A Systematic Coarse-Graining Approach.”
Y. Wei, M.J. Solomon, and R.G. Larson, J. Rheol. 60:1301-1315, 2016 “Quantitative Nonlinear Thixotropic Model with Stretched Exponential Response in Transient Shear Flows.”
H. Rezvantalab, D.J. Beltran-Villegas, and R.G. Larson, Phys. Rev. Lett., 117:128001 2016 “Rotator-to-Lamellar Phase Transition in Janus Colloids Driven by Pressure Anisotropy.”
A. Salehi, P. and R.G. Larson, Macromolecules 49:9706-9719 2016 “A Molecular Thermodynamic Model of Complexation in Mixtures of Oppositely Charged Polyelectrolytes with Explicit Account of Charge Association/Dissociation.”
F. Yuan and R.G. Larson J. Phys. Chem. B. 119:12540-12551 2015 “Multiscale Molecular Dynamics Simulations of Model Hydrophobically Modified Ethylene Oxide Urethane Micelles.”
P.S. Desai, B.-G. Kang, M. Katzarova, R. Hall, Q.F. Huang, S. Lee, M. Shivokhin, T. Chang, D.C. Venerus, J. Mays, J.D. Schieber, and R.G. Larson, Macromolecules 49:4964-4977 2016 “Challenging Tube and Slip-Link Models: Predicting the Linear Rheology of Well-Characterized Star and Linear 1,4-Polybutadienes.”
C.A.S. Batista, R.G. Larson, and N.A. Kotov, Science 350:6257 2015 “Nonadditivity of Nanoparticle Interactions.”
T. Mandal, R. Marson, and R.G. Larson, Soft Matter, 12: 8246-8255 2016 “Coarse-grained Modeling of Crystal Growth and Polymorphism of a Model Pharmaceutical Molecule.”
S. Wang, and R.G. Larson, Langmuir, 31:1262-1271, 2015 “Coarse-Grained Molecular Dynamics Simulation of Self-Assembly and Surface Adsorption of Surfactants Using an Implicit Water Model.”
F. Yuan, S. Wang, and R.G. Larson Langmuir, 31:1336-1343, 2015 “Potentials of Mean Force and Escape Times of Surfactants from Micelles and Hydrophobic Surfaces Using Molecular Dynamics Simulations.”
D.J. Beltran-Villegas, D.J. Schultz, B.A. Nguyen, H.P. Nguyen, S.C. Glotzer, and R.G. Larson, Soft Matter 10:4593-4602 2014 “Phase Behavior of Janus Colloids Determined by Sedimentation Equilibrium.” (cover article)
J. Liu and R.G. Larson, J. Chem. Phys. 138:174904 2013 “Brownian Dynamics Method for Simulation of Binding Kinetics of Patterned Colloidal Spheres with Hydrodynamic Interactions."
