Applied Physics Seminar: Interfacing the Brain Optically and Electrically
Euisik Yoon, Professor of Electrical Engineering and Computer Science and Professor of Biomedical Engineering, College of Engineering, University of Michigan
Abstract: In this talk, I will review the evolution of Michigan neural probe technologies toward scaling up the number of recording sites, enhancing the electrical recording reliability, and neuromodulation optically. We investigated scaling of probe geometry to reduce probe surface area and exploring polymer materials
for providing flexibility in the shank body to reduce micromotion effects. Modular system integration and compact 3D packaging approaches have been explored to realize high-density neural probe arrays for recording of more than 1,000 channels simultaneously. In order to obtain optical neuromodulation, we monolithically integrated optical waveguides on the silicon probe shank to bring light to the probe tips. We could successfully validate excitation and inhibition of neural activities by switching the wavelengths delivered to the distal end of the waveguide. Recently, we directly integrated 128 micro-LEDs on the probe shank to achieve high spatial temporal modulation of neural circuits. We have demonstrated independent
control of distinct cells ~50 μm apart and of differential somato-dendritic compartments of single neurons in the CA1 pyramidal layer of anesthetized and freely-moving mice.
for providing flexibility in the shank body to reduce micromotion effects. Modular system integration and compact 3D packaging approaches have been explored to realize high-density neural probe arrays for recording of more than 1,000 channels simultaneously. In order to obtain optical neuromodulation, we monolithically integrated optical waveguides on the silicon probe shank to bring light to the probe tips. We could successfully validate excitation and inhibition of neural activities by switching the wavelengths delivered to the distal end of the waveguide. Recently, we directly integrated 128 micro-LEDs on the probe shank to achieve high spatial temporal modulation of neural circuits. We have demonstrated independent
control of distinct cells ~50 μm apart and of differential somato-dendritic compartments of single neurons in the CA1 pyramidal layer of anesthetized and freely-moving mice.
| Building: | West Hall |
|---|---|
| Event Type: | Lecture / Discussion |
| Tags: | Engineering, Physics |
| Source: | Happening @ Michigan from Applied Physics |
