Defense Dissertation: An Online Actor Critic Algorithm and a Statistical Decision Procedure for Personalizing Intervention
Huitian Lei
Abstract:
Increasing technological sophistication and widespread use of smartphones and wearable devices provide opportunities for innovative health interventions. An Adaptive Intervention (AI) personalizes the type, mode and dose of intervention based on users' ongoing performances and changing needs. A Just-In-Time Adaptive Intervention (JITAI) employs the real-time data collection and communication capabilities that modern mobile devices provide to adapt and deliver interventions in real-time. The lack of methodological guidance in constructing data-based high quality JITAI remains a hurdle in advancing JITAI research despite its increasing popularity. In the first part of the dissertation, we make a first attempt to bridge this methodological gap by formulating the task of tailoring interventions in real-time as a contextual bandit problem. Under the linear reward assumption, we choose the reward function (the "critic") parameterization separately from a lower dimensional parameterization of stochastic JITAIs (the "actor"). We provide an online actor critic algorithm that guides the construction and refinement of a JITAI. Asymptotic properties of the actor critic algorithm, including consistency, asymptotic distribution and regret bound of the optimal JITAI parameters are developed and tested by numerical experiments. We also present numerical experiment to test performance of the algorithm when assumptions in the contextual bandits are broken. In the second part of the dissertation, we propose a statistical decision procedure that identifies whether a patient characteristic is useful for AI. We define a discrete-valued characteristic as useful in adaptive intervention if for some values of the characteristic, there is sufficient evidence to recommend a particular intervention, while for other values of the characteristic, either there is sufficient evidence to recommend a different intervention, or there is insufficient evidence to recommend a particular intervention.
Increasing technological sophistication and widespread use of smartphones and wearable devices provide opportunities for innovative health interventions. An Adaptive Intervention (AI) personalizes the type, mode and dose of intervention based on users' ongoing performances and changing needs. A Just-In-Time Adaptive Intervention (JITAI) employs the real-time data collection and communication capabilities that modern mobile devices provide to adapt and deliver interventions in real-time. The lack of methodological guidance in constructing data-based high quality JITAI remains a hurdle in advancing JITAI research despite its increasing popularity. In the first part of the dissertation, we make a first attempt to bridge this methodological gap by formulating the task of tailoring interventions in real-time as a contextual bandit problem. Under the linear reward assumption, we choose the reward function (the "critic") parameterization separately from a lower dimensional parameterization of stochastic JITAIs (the "actor"). We provide an online actor critic algorithm that guides the construction and refinement of a JITAI. Asymptotic properties of the actor critic algorithm, including consistency, asymptotic distribution and regret bound of the optimal JITAI parameters are developed and tested by numerical experiments. We also present numerical experiment to test performance of the algorithm when assumptions in the contextual bandits are broken. In the second part of the dissertation, we propose a statistical decision procedure that identifies whether a patient characteristic is useful for AI. We define a discrete-valued characteristic as useful in adaptive intervention if for some values of the characteristic, there is sufficient evidence to recommend a particular intervention, while for other values of the characteristic, either there is sufficient evidence to recommend a different intervention, or there is insufficient evidence to recommend a particular intervention.
| Building: | West Hall |
|---|---|
| Event Type: | Workshop / Seminar |
| Tags: | Dissertation |
| Source: | Happening @ Michigan from Department of Statistics |
