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Thursday Seminar: Helminth-microbe co-infection: insights from a natural system

Thursday, October 8, 2015
12:00 AM
1210 Chemistry

African buffalo
Coinfection with worms can have profound effects on a host’s response to microbes, and an increasing number of studies are investigating the consequences of worm-microbe coinfection in laboratory settings. To better understand the dynamics of coinfection in natural systems, we used a free-ranging population of African buffalo to explore the consequences of worm infection for bovine tuberculosis (BTB). We followed 200 animals for four years to test the effects of anthelmintic treatment and host resistance on individual and population-level outcomes of BTB infection. We found that de-worming had no effect on individual risk of infection, but enhanced survival of BTB-infected individuals, translating into a higher basic reproductive number for BTB with treatment. Host resistance to worm infection also had no effect on individual risk, but buffalo that were naturally worm-free were more likely to die of BTB infection. The distinct effects of de-worming versus natural resistance on BTB severity arise from differences in BTB dissemination in the body. Our work shows that different ways of being worm-free (i.e. artificial treatment vs. natural resistance) have distinct outcomes for microbial coinfection.

Host: Professor Nyeema Harris

Coffee and snacks served at 4 p.m.